Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder

• Conditions: Major Depressive Disorder
• Interventions: Drug: antidepressant

• Registration Number: NCT03230682
• Lead Sponsor: Huashan Hospital

Brief Summary

Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week. Our observation study including 80 MDD patients will access resting-state function MRI to finding factors which infuencing early improvemrnt, respone and remission of antidepressants.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-07
• Study First Submitted: 2017-07-24
• Study Start: 2017-07-25
• Study First Submitted QC: 2017-07-25
• Last Update Submitted: 2017-07-25
• Study First Posted: 2017-07-26
• Last Update Posted: 2017-07-26
• Primary Completion: 2018-06-11
• Study Completion: 2018-07-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• right-handed; HAMD-17 more than 17; diagnosed with MDD by the Structured Clinical Interview for DSM-IV

Exclusion Criteria

• patients diagnosed with other condition in DSM-IV Axis I; pregnency; Thyroid disease; Heart Disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
major depressive disorder	antidepressant	-

Primary Outcome Measures

Name	Time	Method
Early improvement	the second week of treatment	obtain 20% decrease of HAMD-17

Secondary Outcome Measures

Name	Time	Method
Response	the 12th week of treatment	obtain 50% decrease of HAMD-17

Trial Locations

Locations (1)

Dept. of Neurology, Huashan Hospital, Fudan University; 🇨🇳 Shanghai, Shanghai, China