NCT02704117进行中（未招募）3 期
Neurocircuitry of OCD: Effects Of Modulation
适应症
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Change in activation of pre-supplementary motor area/dorsal anterior cingulate cortex (pSMA/dACC) on functional magnetic resonance imaging (fMRI) during the Multi-Source Interference task (MSIT)
研究概览
简要总结
The purpose of this study is to test the effects of non-invasive neuromodulation, transcranial magnetic stimulation on brain function in individuals with obsessive-compulsive disorder (OCD). This study is focused on the mechanism(s) by which brain stimulation might change the functioning of regions implicated in OCD, and thereby inform possible future therapeutic uses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Current primary OCD diagnosis and current Y-BOCS total score of ≥16
- •18-70 years of age
- •Ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
- •No use of psychiatric medications or stable psychiatric medication use for a minimum of 6 week prior to study entry
- •Ongoing psychotherapy allowed if already established for three months or more before study entry
排除标准
- •History of primary psychotic disorder or bipolar disorder
- •Present acute suicidality
- •History of head injury, epilepsy, or other clinically significant neurological illness except tic disorders
- •Active systemic medical (metabolic, endocrine, chronic inflammatory, vascular, autoimmune) disease
- •Premorbid intelligence quotient (IQ) estimate < 80
- •Visual disturbance (<20/40 Snellen visual acuity, corrected)
- •Current, or alcohol or illicit substance abuse/dependence in the last 3 months
- •Contraindications to TMS or MRI: metallic foreign objects, e.g., aneurysm clips/pacemakers, or questionable history of metal fragments, claustrophobia
- •Women who are pregnant or breastfeeding. All women participants of reproductive age are required to have a negative pregnancy test prior to enrollment and use medically acceptable birth control throughout the study (barrier and/or oral contraceptives)
- •Current psychotic symptoms
- •An increased risk of seizure, determined by history
- •Medications judged to notably affect cortical excitability e.g., anticonvulsants or high-dose benzodiazepines (> 4 mg/day of clonazepam or equivalent)
- •Predominant hoarding symptoms
结局指标
主要结局
Change in activation of pre-supplementary motor area/dorsal anterior cingulate cortex (pSMA/dACC) on functional magnetic resonance imaging (fMRI) during the Multi-Source Interference task (MSIT)
时间窗: Baseline and 6 months
次要结局
- Change in Yale-Brown Obsessive Compulsive Scale (Y-BOCS)(Baseline and 6 months)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Rapid Non-Invasive Brain Stimulation for OCD (oTMS)OCDNCT03404609Stanford University7
已完成
2 期
Neuromodulation With Transcranial Direct Current Stimulation (tDCS) to Control Excess WeightOverweight and ObesityNCT03351426University of Alcala40
终止
不适用
TMS as a Treatment for Apathy in Alzheimer's DiseaseAlzheimer DiseaseApathy in DementiaNCT05389644Massachusetts General Hospital3
Unknown
不适用
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?Chronic HeadacheMigraineNCT00286923Emerald City Headache Organization10
已完成
不适用
Cognitive Stimulation StudyHealthyNCT02067689University of Florida18