Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
- Conditions
- Open Angle Glaucoma
- Interventions
- Diagnostic Test: Optical Coherence Tomography- AngiographyDiagnostic Test: Photopic negative response
- Registration Number
- NCT05104294
- Lead Sponsor
- Benha University
- Brief Summary
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
- Detailed Description
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 76
- Age of 30 years or older for both control and glaucoma groups.
- Spherical equivalent (SE) between -2 and +2 D.
- No history of previous eye surgery, trauma, or systemic diseases.
- Spherical equivalent greater than +/- 2.00 diopters (D).
- Media opacity as (cataract or corneal scar).
- Any history of ocular surgeries or trauma.
- Optic nerve anomaly or other retinal diseases.
- Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Control Group Optical Coherence Tomography- Angiography 80 eyes of 40 healthy subjects as control group. mild Primary Open Angle Glaucoma group (Group I) Photopic negative response 28 eyes of 16 patients with mild primary open angle glaucoma as group I. Control Group Photopic negative response 80 eyes of 40 healthy subjects as control group. mild Primary Open Angle Glaucoma group (Group I) Optical Coherence Tomography- Angiography 28 eyes of 16 patients with mild primary open angle glaucoma as group I. moderate to severe Primary Open Angle Glaucoma group (Group II) Optical Coherence Tomography- Angiography 44 eyes of 24 patients with moderate to severe primary open angle glaucoma as group II. moderate to severe Primary Open Angle Glaucoma group (Group II) Photopic negative response 44 eyes of 24 patients with moderate to severe primary open angle glaucoma as group II.
- Primary Outcome Measures
Name Time Method Correlation between vascular, structural and functional changes of the peripapillary retinal nerve fiber and macular ganglion cell complex in patients with open angle glaucoma. Immediately after OCTA and electroretinogram diagnostic tests for each eye. Correlation between RNFL thickness and GCC measured by OCT-A with implicit time and amplitude of Photopic Negative Response (PhNR) measured by electroretinogram.
- Secondary Outcome Measures
Name Time Method Assess the validity of OCTA parameters and PhNR in early detection of glaucoma changes. Immediately after OCTA and electroretinogram diagnostic tests for each eye. Changes in the parameters were measured by OCT-A as Superficial and deep vessel Density.
Trial Locations
- Locations (1)
Benha University
🇪🇬Banhā, Benha, Egypt