ED90 of intrathecal 1% chloroprocaine in day-case knee arthroscopy: a Biased-Coin-Up-and-Down sequential allocation trial

Completed

• Conditions: spinal anaesthesia; 10009720

• Registration Number: NL-OMON47564
• Lead Sponsor: VUMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 2021-12-28
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Scheduled ambulatory knee arthroscopy;
Age * 18 years;
ASA physical status I-III

Exclusion Criteria

Allergy to chloroprocaine;
Contraindication to neuraxial anaesthesia;
Allergy to local anesthetics of the ester-type: cocaine, oxybuprocaine, procaine, tetracaine.
Allergy to parabens or paraaminobenzoic-acid (PABA)
Pseudocholinesterase deficiency
Previous neuropathy to the lower extremities;
Pregnancy;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Successful anesthesia. Anesthesia is considered successful when:<br /><br>1. Complete loss of cold sensation at the L2 dermatome, AND<br /><br>2. Pain is 0-2 following inflation of the tourniquet and zero upon incision<br /><br>3. Pain is 0-3 during surgery</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Motor block<br /><br>TNS (Transient Neurologic Syndrom)<br /><br>Urine retention<br /><br>Patient satisfaction</p><br>