Correlation between postoperative neurocognition and perioperative subclinical cerebral ischemia in cardiac surgery patients (a retrospective analysis)
- Conditions
- Postoperative cognitive decline (no ICD-code available)
- Registration Number
- DRKS00033944
- Lead Sponsor
- Kerckhoff-Klinik, Heart and Brain Research Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 332
Inclusion Criteria
Elective cardiac surgical procedure (on-pump)
- Coronary Artery Bypass Grafting (CABG)
- Aortic Valve Replacement (AVR)
- Mitral Valve Replacement/Reconstruction (MVR)
- Combination (CABG+AVR, CABG+MVR, AVR+MVR, CABG+AVR+MVR)
Good knowledge of the German language, as the neuropsychological tests are language-dependent.
Patient age > 18
Written consent from patients to participate in the study
Exclusion Criteria
None
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method How frequently do postoperative cognitive deficits (POCD) occur in patients with subclinical cerebral ischemia (SCI)?
- Secondary Outcome Measures
Name Time Method 1.Does the volume of SCI correlate with the extent of POCD?<br>2.Are there specific cortical topographic regions with SCI associated with specific postoperative neuropsychological dysfunctions?<br>3.Are there specific cortical networks with SCI associated with specific postoperative neuropsychological dysfunctions?<br>4.Are there specific vascular territories with SCI associated with specific postoperative neuropsychological dysfunctions?<br>5.Are there preoperative neurocognitive impairments associated with the risk of developing postoperative SCI?<br>6.Are there preoperative psychopathological disorders (depression, anxiety) associated with the risk of developing postoperative SCI?<br>7.Does the extent of preoperative cognitive impairments correlate with the volume of SCI?<br>8.Which perioperative variables (duration of surgery, bypass time, clamp time) are associated with postoperative SCI?