High-Protein vs Low-Carbohydrate Diets for Weight Loss

Not Applicable

Completed

• Conditions: Obesity; Appetite control; Diet and Nutrition - Obesity

• Registration Number: ACTRN12619000209190
• Lead Sponsor: The University of Auckland Research Office

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-13
• Study Completion: 2019-12-07
• Last Update Posted: 21 February 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 149

Inclusion Criteria

i. Females aged between 18 and 65 years.
ii. Obese (BMI 30 kg/m2 - 45kg/m2) with a maximum body weight of 130kg
iii. Otherwise healthy

Exclusion Criteria

i. Recent body weight loss/gain >5% within previous 3 months
ii. Currently taking part in an active diet program
iii. Current medications or other conditions known to affect body weight and appetite
iv. Previous bariatric surgery
v. Diagnosed with impaired liver or kidney function
vi. Significant current disease such as type 2 diabetes, cardiovascular disease, or cancer; or digestive disease including inflammatory bowel syndrome/disease (IBS/D), ulcerative colitis (UC), Crohn's disease
vii. Systolic blood pressure greater than or equal to 160 mmHg and/or diastolic blood pressure greater than or equal to 100mmHg
viii. Depression or any other anxiety disorder known to affect appetite
ix. Unable to consume food items included in the study, or hypersensitivities or allergies to these foods (based on Food Preference Questionnaire)
x. Smokers or ex-smokers who have given up smoking for less than 6 months
xi. Pregnant or breastfeeding women
xii. Unwilling/unable to comply with the study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in body weight as assessed using a calibrated digital scale.[We are primarily interested in the difference between baseline and 8 weeks after intervention commenced. However, we also collect the body weight data at 4 weeks after the intervention commenced.]

Secondary Outcome Measures

Name	Time	Method
Objective markers of appetite as assessed using plasma concentration of appetite-related biomarkers (CCK, GLP-1, PYY)[At baseline and 8 weeks after intervention commenced.];Subjective feelings of appetite as assessed using Visual Analogue Scales (VAS)[At baseline and 8 weeks after intervention commenced.];Change in body composition (fat mass and fat-free mass) as assessed using a DEXA scan.[At baseline and 8 weeks after intervention commenced.]