Lung Recruitment and Postoperative CPAP

Phase 2

Completed

• Conditions: Anesthesia

• Registration Number: NCT02502279
• Lead Sponsor: Assiut University

Brief Summary

General anesthesia lowers FRC thereby promoting airway closure and absorption atelectasis. Alveolar recruitment manoeuvers recruit collapsed alveoli, increase gas exchange, and improve arterial oxygenation.

Detailed Description

General anesthesia lowers FRC thereby promoting airway closure and absorption atelectasis. Alveolar recruitment manoeuvers recruit collapsed alveoli, increase gas exchange, and improve arterial oxygenation. However, the effect of recruitment manoeuvre is short lasting and does not extend to the post operative period. Postoperative CPAP keeps the lung open and can improve oxygenation in the early postoperative period.

Study Timeline

• Study Start: 2015-07
• Study First Submitted: 2015-07-11
• Study First Submitted QC: 2015-07-17
• Study First Posted: 2015-07-20
• Primary Completion: 2016-02
• Study Completion: 2016-02
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-25
• Last Update Posted: 2017-03-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Pediatric patients undergoing laparoscopic surgery for abdominal cryptorchidism.

Exclusion Criteria

• Cardio-respiratory illness.
• Unsatisfactory preoperative peripheral arterial oxygen saturation.
• Unsatisfactory preoperative hemoglobin level.
• Neurological or psychiatric disease.
• Children with a BMI >95th percentile for age.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
(A-a) DO2	1 hour after extubation	arterial blood gas will be withdrawn 1 hour after extubation and the alveolar minus arterial oxygen difference will be calculated for assessment of oxygenation

Secondary Outcome Measures

Name	Time	Method
PaCO2	intra-operative and 1hour postoperative	arterial blood gas samples will be withdrawn to assess PaCO2.
PaO2	intra-operative and 1hour postoperative	arterial blood gas samples will be withdrawn to assess Pa O2.
PH	intra-operative and 1hour postoperative	arterial blood gas samples will be withdrawn to assess PH.
Respiratory mechanics	Intraoperative	intra-operative ventilator data will be recorded to measure respiratory mechanics such as dynamic and statistic compliance
non invasive mean arterial pressure	intraoperative and 1hour postoperative	non invasive mean arterial pressure will be recorded before and after recruitment manouvre, after pneumoperitonium and after pneumoperitonium deflation
Heart rate	intraoperative and 1hour postoperative	the heart rate will be recorded before and after recruitment manoeuvre, after pneumoperitonium, and after pneumoperitonium deflation and early postoperative..
Peripheral arterial oxygenation SPO2%	intraoperative and 1hour postoperative	The SPO2% will be recorded before and after recruitment manouvre, after peumoperitoneum inflation and after pneumoperitoneum deflation and early postoperative

Trial Locations

Locations (1)

Pediatric hospital; 🇪🇬 Assiut, Assiut governorate, Egypt