Therapeutic Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis and Periarticular Tissue Injury
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 300
- Locations
- 2
- Primary Endpoint
- MRI
Study Overview
Brief Summary
To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.
- •The preoperative routine tests and examinations revealed no contraindications.
- •Revised sentence: "Informed consent of the patient
Exclusion Criteria
- •The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.
- •Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.
- •In injection site or damage to the skin.
- •Patients with tumors or undergoing radiotherapy and chemotherapy.
- •Pregnant or breastfeeding women.
- •Individuals with mental illnesses who are unable to cooperate with follow-up procedures.
- •Contraindications for MRI、Patients or their families do consent to participate in the study.
- •Other circumstances that render participation in the study unsuitable.
Arms & Interventions
postoperative (3 months)
The patients were injected with PRP.
Intervention: Sodium hyaluronate injection (Drug)
postoperative (6 weeks)
The patients were injected with PRP.
Intervention: Sodium hyaluronate injection (Drug)
Outcomes
Primary Outcomes
MRI
Time Frame: pre-operation,3 weeks after treatment, 6 months after treatment
The injury of ligaments, meniscus, and the knee joint was assessed using MRI.
X-ray
Time Frame: pre-operation,3 weeks after treatment, 6 months after treatment
The postoperative plain X-ray film was utilized for the assessment of knee joint deformity, stenosis of the joint space, and hyperplasia of osteophytes.
CT
Time Frame: pre-operation,3 weeks after treatment, 6 months after treatment
The application of three-dimensional CT scan for the assessment of articular cartilage defects.
Secondary Outcomes
No secondary outcomes reported