Effect of the Platelet-Rich Plasma (PRP) injection in primary manifestations of knee osteoarthritis in patients who refer to rheumatology clinic of Kowsar hospital, Semnan

Introduction:
Osteoarthritis (OA) has high prevalence due to various reasons such as occupational and environmental conditions. Pain and discomfort decreased quality of life in patients with osteoarthritis. There is known treatment for the disease. According to the effect of PRP single injection in some reports, in this study we aimed to assess the effect of single injection of platelet-rich plasma(prp) on the symptoms in early stages of knee OA.
Patient and methods:
In randomized, double-blind, clinical trial 34 patients with early symptoms of knee osteoarthritis in the age range 40-65 years, with a history of chronic knee pain for at least 12 months and kellgren –lawrence radiological criteria were enrolled. Three ml of autologous prp injected in both knees for patients in case group patients and patients in the control group received placebo injected into the another joint. Patients were assessed at baseline and 3 and 6 months after the intervention by IKDC,EQ-VAS,WOMAK and tegner criteria.
Result:
The difference of the mean IKDC score before and three months after injection as well as three and six months after the injection was statistically significant in the two groups(p=0.040), but was not significant before and six months after injection.
Difference of the WOMAC,EQ-VAS and tegner scores were not significant in the two groups.
Conclusion:
The results showed that based on the IKDC criteria, single platelet-rich plasma injection can be effective in pain relieving and improve the patients’ performance.