Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis

Phase 2

• Conditions: Osteoarthritis of the Knee
• Interventions: Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors); Drug: Hyaluronic acid

• Registration Number: NCT01270412
• Lead Sponsor: Meir Medical Center

Brief Summary

Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The aim is to examine the effect of a platelet-derived preparation rich in growth factors (PRGFs) in OA of the knee.

Detailed Description

Autologous platelet-secreted growth factors (GFs) may have therapeutic effects in osteoarthritis (OA) capsular joints via multiple mechanisms. The investigators aim is to examine the effect of a platelet-derived preparation rich in growth factors(PRGFs) in OA of the knee, using parameters of pain, function, quality of life and safety.

Study Timeline

• Study First Submitted: 2010-12-20
• Study First Submitted QC: 2011-01-04
• Study First Posted: 2011-01-05
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-16
• Last Update Posted: 2011-07-19
• Study Start: 2011-09
• Primary Completion: 2012-12
• Study Completion: 2013-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• age 40-75 years old
• diagnosed Oa of the knee more then 1 year
• no knee deformation

Exclusion Criteria

• mental of physical disabilities
• pregnancy
• deformities of the knee

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Platelet Rich Plasma (Preparation Rich in Growth Factors)	Platelet Rich Plasma (Preparation Rich in Growth Factors)	intra articular injection 6ml of platelet-derived preparation rich in growth factors
Hyaluronic acid	Platelet Rich Plasma (Preparation Rich in Growth Factors)	Drug: hyaluronic acid 20 mg / 2 ml Other Name: Arthrease
Hyaluronic acid	Hyaluronic acid	Drug: hyaluronic acid 20 mg / 2 ml Other Name: Arthrease

Primary Outcome Measures

Name	Time	Method
Improvement in pain, function, quality of life and activity level in knee osteoarthritis	1 -2 years	Improvement in pain, function, quality of life, activity level - using scores adapted to measure these parameters in knee osteoarthritis.

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar-Saba, Israel