Effects of exposure to environmental chemicals on development during adolescence

Completed

• Conditions: Developmental disorders; 10013317; 10057167; 10018515

• Registration Number: NL-OMON40996
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 190

Inclusion Criteria

- member of one of the existing cohorts in which prenatal exposure to environmental chemicals have been measured
- written informed consent from the child and both parents

Exclusion Criteria

No exclusioncriteria

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- serum levels of thyroid hormone parameters;<br /><br>- neuropsychological development;<br /><br>- pubertal development (stage of breast-, genital-, pubic hair- and axillar<br /><br>hair development; testicular volume; age at menarche/first ejaculation; serum<br /><br>levels of sex hormones);<br /><br>- physical examination: height, weight, waist circumference and body fat<br /><br>percentage;<br /><br>- serum levels of parameters of energy metabolism (fasting glucose, insulin,<br /><br>HbA1C, leptin, adiponectin, triglycerides, total cholesterol, HDL- and<br /><br>LDL-cholesterol).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- serum levels of PCBs, OH-PCBs and PBDEs;<br /><br>- urine levels of BPA, phthalates and PFCs.</p><br>