The perioperative microbiota composition in colorectal surgery patients receiving oral antibiotics (SDD) or no oral antibiotics

Conditions: 10017998
10017990
Perioperative microbiota
10004018

Registration Number: NL-OMON53205

Lead Sponsor: Spaarne Gasthuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

Patients 18 years and older
Dutch or English speaking
Candidate for elective laparoscopic/open colorectal surgery with a primary
anastomosis
Biopsy-proven colorectal carcinoma (or a high index of suspicion of carcinoma
on biopsy) with no imaging signs of distant metastasis

Exclusion Criteria

No primary anastomosis or deviating stoma
Recent abdominal surgery (<4 weeks) or recent (<3 months) oral antibiotic
treatment
Pregnancy
Unable to give informed consent
History of inflammatory bowel disease
ASA grade IV
Immune suppressing medication

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective of this study is to evaluate the differences in<br /><br>microbiome composition and diversity between different microbiota samples. To<br /><br>achieve this objective, we will employ various statistical tests, including<br /><br>t-tests or ANOVA, to compare the alpha and beta diversity measures between<br /><br>microbiota samples. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>For the secondary objective we compare the rectal and anastomotic microbiota<br /><br>composition for right and left-sided resections and evaluate the differences<br /><br>between these groups. Specifically, we will use statistical tests, such as<br /><br>t-tests or ANOVA, to compare the alpha and beta diversity measures between<br /><br>rectal and anastomotic microbiota for right and left-sided resections.</p><br>