The role of intestinal microbiota composition and intestinal permeability in the development of (complicated) diverticular disease.

Completed

• Conditions: Outpocketings of colonic mucosa; 10013535

• Registration Number: NL-OMON35377
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 210

Inclusion Criteria

- Age >= 50 years and <= 75 years
- Scheduled for colonoscopy
- Written informed consent
- Patient group: The presence of diverticulosis, diagnosed during the scheduled conoloscopy
- Control group: During the scheduled colonoscopy, diverticulosis or other gastrointestinal and liver diseases are absent. In other words, the colonoscopy is qualified as a *normal* colonoscopy.

Exclusion Criteria

- Age < 18 years
- Presence of gastrointestinal and liver diseases, such as inflammatory bowel disease
- Use of NSAID*s and proton pump inhibitors, during the 5-day time period prior to endoscopy
- Alcohol intake above 14 consumptions per week for males and 7 consumption per week for females
- (Sub)total colectomy or hemicolectomy.
- Refusal to participate in this study

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the intestinal microbiota composition and<br /><br>epithelial integrity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>