The influence of the intestinal microbiome on the development of postoperative complications after elective colon surgery - a prospective cohort study

• Conditions: K91.83; T79.3; Post-traumatic wound infection, not elsewhere classified

• Registration Number: DRKS00014059
• Lead Sponsor: niversitätsklinikum FreiburgInstitut für Umweltmedizin und KrankenhaushygieneUni-Zentrum Naturheilkunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-02-21
• Study Completion: 2020-10-31
• Results First Posted: 2022-05-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 127

Inclusion Criteria

Conservative and elective surgery, colon surgery (left hemicolectomy, right hemicolectomy, sigmoid resection, deep anterior rectal resection, continuity restoration), maintenance of continuity (physiological bowel transit with regular defecation is possible), no antibiotic or probiotic therapy at least four weeks prior to surgery, no long term therapy with opiates, no permanent use of antiemetics or intestinal stimulants (the single use of a laxative, for example, to prepare for a colonoscopy is not an exclusion criterion)

Exclusion Criteria

Emergency surgery, creation of a terminal or protective anus praeter, no physiological nutritional passage (from oral to anal) possible, antibiotic pretreatment must have been completed at least four weeks prior to surgery, inability to pass stool sample, inability to complete a questionnaire, lack of compliance and participation carrying out the study, unresponsive

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in intestinal microbiome diversity (measured preoperatively and on the 6th postoperative day) between patients with complication-rich and patients with complication-free course as measured by Shannon's index after sequence analysis of a stool sample