Changes of the gastrointestinal microbiome in perioperative patients

• Conditions: A41; C25; Z98; Other sepsis; Malignant neoplasm of pancreas; Other postsurgical states

• Registration Number: DRKS00008535
• Lead Sponsor: niversitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-10-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

*Written consent form of study participant or his appointed representative
*Age > 18 years
*undergoing a whipple-operation

Exclusion Criteria

*Non-fulfillment of inclusion criteria
*chronic inflammatory diseases
*antibiotic allergies
*Refusal of participation in the study

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
*Changes in the gastrointestinal microbiome under antibiotic therapy (stool samples: preoperative, 1d, 3d, 5d, 7d)<br>*Comparison of the microbiome changes and clinical complications (preoperative, 1d, 3d, 5d, 7d)

Secondary Outcome Measures

Name	Time	Method
*Comparison of the micobiome changes and outcomerelevance at the timepoints: preoperative, 1d, 3d, 5d, 7d (addditionally: reevaluation: 28d, 90d)