Gut microbiota and its metabolite changes in post-myocardial infarction patients

• Conditions: Acute coronary syndrome; ACS; Gut microbiota; Blood metabolites; TMAO; LPS; Troponin

• Registration Number: TCTR20220630001
• Lead Sponsor: The faculty of Medicine endowment fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-30
• Study Completion: 2023-07-24
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Post ACS group
1. Age 18 to 80 years old
2. Diagnosed of acute coronary syndrome (ST-elevation myocardial infarction or non-ST-elevation myocardial infarction) patients receiving coronary angiography or revacularization within 12 to 24 hours at Cardiovascular and Critical Care unit in Maharaj Nakorn Chiang Mai hospital

Normal population group
1. Age 18 to 80 years old
2. Healthy volunteer who has age sex and comorbidities matched at Outpatients clinic of Internal medicine department at Maharaj Nakorn Chiang Mai hospital
2.1 Hypertension defined as
home BP more than 135 over 85
or on antihypertensive medication
2.2 Diabetes mellitus type 2 defined as HbA1c more than 7 percent or less than 7 percent
FBS more than 126
random glucose more than 200
on antidiabetic medication
2.3 Dyslipidemia defined as
LDL more than 70
or on anti lipid medication

Exclusion Criteria

1. Cardiac arrest and cannot be recover
2. Life expectancy less than 1 year
3. History of acute cardiovascular events (including acute coronary syndrome, stroke, heart failure, acute/critical limb ischemia)
4. History of heart failure reduced ejection fraction
5. History of antibiotics or probiotics in past 4 weeks before recruitment
6. Active infection within 1 week
7. Severe valvular heart disease
8. Informed consent refusal

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gut microbiota species and blood metabolites 3 months species and diversity

Secondary Outcome Measures

Name	Time	Method
-Gut and blood microbiota association in individual patients with acute coronary syndrome at 0 and 3 months 3 months not statistical method