Modulation of the intestinal microbiome, and its effects on endurance exercise capacity in moderately trained individuals

Completed

• Conditions: spierfunctie; exercise performance

• Registration Number: NL-OMON49125
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 34

Inclusion Criteria

1. Aged from 18- 40 years
2. 18.5 < BMI < 25 kg*m-2
3. Weight-stable for at least 90 days prior to participation (no change in
bodyweight, i.e. < 3kg).
4. Recreational active (performing non-competitive physical endurance exercise
at least two times per week with a minimum duration of 60 minutes per exercise
bout)

Exclusion Criteria

1. Smoking
2. Performing regular resistance training (3+ times per week, carrying out
progressive training)
3. Subject following an overly imbalanced or restrictive diet as per
nutritional advice
4. Concurrent systemic disease and/or laboratory abnormalities considered by
investigators to be detrimental for the participants safety or potentially
interfering with the study procedures and/or study outcome
5. Hypertension (according to WHO criteria) and/or cardiovascular disease
6. Abdominal surgery interfering with gastrointestinal function, upon judgement
of the medical doctor, who will decide in-or exclusion based on the surgery
applied
7. Participants who received antibiotics in the previous 90 days to the start
of study
8. Use of other medication will be reviewed by a medical doctor, who will
decide on in- or exclusion based on the drug(s) used
9. Use of laxatives within 14 days prior to the study
10. Using medications for gastric or intestinal complaints
11. Drug use, interfering with any of the outcome parameters of this study; to
be decided by the person who is medically responsible for this study
12. Self-admitted lactose intolerance
13. Having donated blood in the 3 months prior to the study
14. Administration of probiotic or prebiotic supplements, investigational drugs
or participation in any scientific intervention study, which may interfere with
this study (to be decided by the principle investigator), in the 14 days prior
to the study
15. History of side effects towards intake of prebiotic supplements
16. Use of proton pump inhibitors

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The most important parameter is the outcome of the exercise test until<br /><br>exhaustion.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- the fecal microbiota<br /><br>- biomarkers of metabolic health; fasting glucose, insulin and SCFA<br /><br>- SCFA concentration in the droppings<br /><br>- permeability of the intestines after a single exercise test<br /><br>- permeability of the intestines after intervention</p><br>