Study for the intestinal microflora remodeling and microRNA regulation mechanism of acupuncture in patients with functional constipatio
- Conditions
- Functional Constipation
- Registration Number
- ITMCTR2100005069
- Lead Sponsor
- Chengdu University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Men or women aged 18-60 years;
2. According with Rome IV diagnostic criteria for functional constipation, with a history of constipation of at least half a year;
3. Severe constipation, complete spontaneous defecation <= 2 times a week, and has lasted for more than 3 months;
4. The patients had no special eating habits, anxiety, depression and other mental disorders;
5. At baseline, the patients had difficulty in defecation and dry stool (BSFS <= 3); Did not take any medicine for constipation, including intestinal microecology, probiotics, etc;
6. Did not receive acupuncture treatment for constipation in the past three months and lived in Chengdu or surrounding areas for a long time.
1. History of abdominal or anorectal surgery;
2. Irritable bowel syndrome and organic or drug-induced constipation; Secondary to endocrine, metabolic or neurogenic constipation;
3. Patients with heart, liver, kidney damage or cognitive impairment, aphasia, or unable to cooperate with sample collection and treatment;
4. Pregnancy, lactation, postpartum and allergic constitution;
5. Coagulation dysfunction or anticoagulants such as farwarfarin and heparin have been used.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method gut microbiota;microRNA;weekly complete spontaneous bowel movements;
- Secondary Outcome Measures
Name Time Method weekly spontaneous bowel movements;self-rating anxiety scale;Patient Assessment Constipation Quality of Life;self-rating depression scale;Difficulty in defecating;Bristol Stool Form Scale;