Sleep Disturbances as a Risk Factor in Chronic Kidney Disease
Not Applicable
Completed
- Conditions
- Chronic Kidney Disease
- Interventions
- Other: Controls Short sleepOther: CKD- sleep extension
- Registration Number
- NCT00817427
- Lead Sponsor
- University of Chicago
- Brief Summary
This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Mild to Moderate CKD
- Healthy controls age and gender matched to CKD subjects
- Regular bedtimes of at least 6h/night, sedentary lifestyle
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Exclusion Criteria
- Diabetes
- Current or previous dialysis for more than 1 month
- Uncontrolled hypertension
- Heart failure
- Liver disease
- HIV
- Hemoglobin < 10.5 g/dl
- Treatment with EProcrit, Epogen, or Aranesp
- Bone or organ transplant,
- Use of immunosuppressive drugs within past 6 months
- Current oral contraceptive use
- Current pregnancy
- Chemotherapy for malignancy within past 2 years
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Controls short sleep Controls Short sleep Measures as in baseline but with sleep disruption CKD- Sleep extension CKD- sleep extension Measures as in baseline but with bed time increased by 2 hours
- Primary Outcome Measures
Name Time Method Comparison of chronobiological profiles of renin/aldosterone, sympatho-vagal balance and CV function in CKD subjects to controls at baseline and after extended sleep in CKD subjects and after decreased time and quality of sleep in control subjects. Immediately after intervention.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The University of Chicago
🇺🇸Chicago, Illinois, United States