Sleep Disturbances as a Non-traditional Risk Factor in CKD-Actigraphy
Completed
- Conditions
- Chronic Kidney DiseaseSleep Loss
- Registration Number
- NCT00817674
- Lead Sponsor
- University of Chicago
- Brief Summary
To test if usual at home night time sleep duration as measured with activity monitors and questionnaires will predict changes in kidney function as measured by kidney filtration rate and of cardiovascular function as measured by C-reactive protein in the blood. The study will explore the role of decreased sleep time or decreased sleep quality as a non-traditional risk factor for the progression of CKD and for the development of cardiovascular disease in CKD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 353
Inclusion Criteria
- Mild to Moderate CKD
- Healthy controls age and gender matched to CKD subjects
- Regular bedtimes of at least 6h/night, sedentary lifestyle
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Exclusion Criteria
- Diabetes
- Current or previous dialysis for more than 1 month
- Uncontrolled hypertension
- Heart failure
- Liver disease
- HIV
- Hemoglobin < 10.5 g/dl
- Treatment with EProcrit, Epogen, or Aranesp
- Bone or organ transplant,
- Use of immunosuppressive drugs within past 6 months
- Current oral contraceptive use
- Current pregnancy
- Chemotherapy for malignancy within past 2 years
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CKD progression as measured by changes in GFR and cardiovascular risk as measured by CRP over a 5 year period 5 years
- Secondary Outcome Measures
Name Time Method insulin resistance 5 years
Trial Locations
- Locations (1)
The University of Chicago
🇺🇸Chicago, Illinois, United States