A comparison of a combination drug of an angiotensin II receptor antagonist and a low-dose diuretic vs. a high-dose angiotensin II receptor antagonist in hypertensive patients - Kamanza Anti-Hypertensive Treatment Trial (KAHT-Trial)

Vascular Care Network (VCN) Kamanza study group0 个研究点目标入组 200 人开始时间: 2008年8月1日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•1) Patients under treatment with diuretics 2) Patients with office systolic blood pressure ≥ 180mmHg or office diastolic blood pressure ≥ 110mmHg 3) Patients with malignant hypertension 4) Patients who have stroke, myocardial infarction or other critical vascular complications that required hospitalization within 6 months prior to informed consent 5) Patients with liver dysfunction (ALT [GOT] and/or AST [GPT] over three times the normal value) 6) Patients with renal failure (serum creatinine ≥2.0 mg/dL) 7) Patients with a gout attack or hyperuricemia (≥8.0mg/dL) 8) Pregnant or breast feeding female patients, including one trying to conceive pregnancy during the planned study period 9) Patients with uncontrolled arrhythmia 10) Patients with severe valvular disease including mitral stenosis and incompetence of aortic valve 11) Patients with cardiac insufficiency (NYHA grade III or IV) 12) Patients with a history of hypersensitivity to ingredients of losartan potassium 13) Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 14) Patients who are considered not eligible for the study by the attending doctor due to medical reasons

发起方

Vascular Care Network (VCN) Kamanza study group