Injection of dexmedetomidine into the paravertebral space (where the nerve for the chest section comes out of the vertebra) protects against lung injury during lung surgery when only one lung is being inflated by a breathing machine
Not Applicable
Completed
- Conditions
- Acute lung injuryAcute lung injury following selective radical resection for pulmonary carcinomaRespiratory
- Registration Number
- ISRCTN13000406
- Lead Sponsor
- Henan Provincial People's Hospital
- Brief Summary
2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29907082
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. American Society of Anesthesiologists (ASA) physician status I or II
2. Aged 18-65 years
3. Scheduled for selective radical resection of pulmonary carcinoma
Exclusion Criteria
1. Hypertension
2. Diabetes mellitus
3. Heart diseases
4. Suggestive history of inflammation or coagulation dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Lung injury score.<br> Method: The histological changes of the fixed lung tissue were evaluated by an independent pathologist who was blinded to the study protocols. The lung tissues were embedded in paraffin wax, sectioned (5 µm), and then stained with hematoxylin and eosin. The severity of lung injury was quantified using the 4-point scoring system, which included pulmonary interstitial edema, alveolar edema, alveolar congestion and neutrophil infiltration. Scoring standards were as follows: 0, no change or very mild changes; 1, mild changes; 2, moderate changes; and 3, severe changes. The average lung injury score from three adjacent slices was evaluated. The summation of four scores was recognized as the final lung injury score.<br> Time point: Immediately after the tumor tissue was excised<br>
- Secondary Outcome Measures
Name Time Method