Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Respiratory Failure
- Sponsor
- Università degli Studi di Ferrara
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Regional Ventilation distribution using Electrical Impedance Tomography
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical ventilation for acute respiratory failure.
The main question[s] it aims to answer are:
- to evaluate which weaning trial is associated to a better regional ventilation distribution
- to evaluate which weaning trial can be comparable to ventilation distribution after extubation
Participants will undergo 3 clinically used weaning trials in a random order (cross-over trial). Researchers will compare the different steps to see if regional ventilation distribution is different among the different trial .
Investigators
Savino Spadaro
Principal investigator
Università degli Studi di Ferrara
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 and \< 70 years
- •Ready to be weaned from mechanical ventilation according to clinical criteria
Exclusion Criteria
- •Age \< 18 years or \> 70 years
- •Presence of chest drains
- •Presence of pacemaker/impantable cardiac device;
- •diagnosis of Pneumothorax, or pneumomediastinum
- •Diagnois of neuromuscular diseases
- •Use of neuromuscular blockers in the 48 hours before screening;
- •Body mass index \> 35 kg/m2
- •Refusal to participate of the patient/next of kin
Outcomes
Primary Outcomes
Regional Ventilation distribution using Electrical Impedance Tomography
Time Frame: 2 hours
The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on: * Regional ventilation distribution * Regional inhomogeneity * Regional compliance distribution * Center of Ventilation * Silent Spaces
Secondary Outcomes
- Differences in Regional Ventilation distribution using Electrical Impedance Tomography between weaning trials and post-extubation phase(48 hours)