Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Abdominal Sepsis
- Sponsor
- Università degli Studi di Ferrara
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis. The main question it aims to answer is:
• evaluate if patients admitted after an open abdomen strategy have a different regional ventilation distribution compared to patients in which abdomen is closed at the end of the procedure
Participants will undergo non-invasive monitoring (esophageal pressure and electrical impedance tomography) and an blood gas analysis samples.
Researchers will compare open abdomen group and closed abdomen group to see if the ventilation distribution pattern is different.
Investigators
Savino Spadaro
Principal investigator
Università degli Studi di Ferrara
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 and \< 90 years
- •Admitted to the ICU after emergent laparotomy for abdominal sepsis
- •Acute respiratory failure
Exclusion Criteria
- •Controindications to electrical impedance tomography monitoring
- •body mass index \> 40 kg/m2
- •Haemodinamic instability
- •Pneumothorax - Pneumomediastinum
- •refusal to participate
Outcomes
Primary Outcomes
Chest-wall compliance (Ccw) measured using respiratory parameters from the Ventilator
Time Frame: Day 2
Different chest wall compliance between the two groups measured using the esophageal catheter. Chest wall compliance will be calculated using the data provided from the respiratory monitoring (i.e. esophageal balloon catheter).
Secondary Outcomes
- Regional ventilation distribution measured using Electrical impedance tomography(Day 2)
- Mortality in the intensive care unit(Up to 28 days)
- Infection rate during ICU stay(Up to 28 days)