NCT02626559已完成不适用
Serum Bupivacaine Concentration Levels After Injection of the Knee Joint With a Mixture of Liposomal Bupivacaine and Free Bupivacaine During Total Knee Arthroplasty
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Serum Bupivacaine levels
研究概览
简要总结
Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults of at least 18 years of age having a primary, unilateral total knee arthroplasty with a surgical plan to have an intra-articular injection of a mixture of 266 mg of Exparel, 125 mg of bupivacaine, 1:300,000 epinephrine, and 0.9% saline to make a total volume of 100 ml.
排除标准
- •Known hepatic dysfunction or renal insufficiency (creatinine > 1.5 mg/dL);
- •allergy to the study medications;
- •pregnancy;
- •incarceration;
- •inability to communicate with the investigators;
- •morbid obesity (body mass index > 40 kg/m2).
结局指标
主要结局
Serum Bupivacaine levels
时间窗: 5 minutes to 24 hours after injection
次要结局
未报告次要终点
研究者
Michael Buys
Assistant Professor
University of Utah
研究点 (1)
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