Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee
Completed
- Conditions
- Anesthesia, Local
- Registration Number
- NCT02626559
- Lead Sponsor
- University of Utah
- Brief Summary
Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Adults of at least 18 years of age having a primary, unilateral total knee arthroplasty with a surgical plan to have an intra-articular injection of a mixture of 266 mg of Exparel, 125 mg of bupivacaine, 1:300,000 epinephrine, and 0.9% saline to make a total volume of 100 ml.
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Exclusion Criteria
- Known hepatic dysfunction or renal insufficiency (creatinine > 1.5 mg/dL);
- allergy to the study medications;
- pregnancy;
- incarceration;
- inability to communicate with the investigators;
- morbid obesity (body mass index > 40 kg/m2).
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum Bupivacaine levels 5 minutes to 24 hours after injection
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Uutah
🇺🇸Salt Lake City, Utah, United States