NL-OMON51626招募中不适用
Dietary oxalate absorption and microbiome diversity in patients with nephrolithiasis and hyperoxaluria: a stable isotope technique. - Influence of diet on CaOx stones and hyperoxaluria (DIOX study)
Amsterdam UMC0 个研究点目标入组 60 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 16 至 64（—）
入选标准
- •For this study, we identify four different groups of participants:
- •Group 1: patients with primary hyperoxaluria.
- •Group 2: patients with secondary or unspecified hyperoxaluria
- •Group 3: patients with idiopathic calcium oxalate kidney stones disease.
- •Group 4: control group of healthy volunteers.
- •Inclusion criteria primary hyperoxaluria (group 1):
- •- Age 16 - 60 years
- •- Diagnosed with primary hyperoxaluria (type 1, 2 or 3), confirmed by genetic
- •Inclusion criteria secondary or unspecified hyperoxaluria (group 2):
- •- Age 16 - 60 years
- •- Diagnosed with secondary hyperoxaluria, confirmed by: hyperoxaluria (defined
- •as > 0.5 mmol/1.73m2/day oxalate in 24-hours urine) and confirmed diagnosis of
- •a disease as underlying secondary enteral cause of hyperoxaluria.
- •- Diagnosed with unspecified hyperoxaluria.
- •Inclusion criteria CaOx stone formers (group 3):
- •- Age 16 - 60 years
- •- Recurrent calcium oxalate stones
- •Inclusion criteria healthy volunteers (group 4):
- •- Age 16 - 60 years
- •- Good health, no background of nephrolithiasis, kidney or gastrointestinal
排除标准
- •- eGFR <30 ml/min/1.73m2
- •- Use of drugs affecting the gastrointestinal microbiome
- •- Gastro-intestinal or systemic diseases known to affect microbiome (causes of
- •secondary hyperoxaluria excluded)
研究者
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