Extreme Large Core Infarct Stroke within 24 Hour Time Window: A Multi-center, Prospective, Chinese Cohort of Endovascular Thrombectomy in Acute Stroke

Not Applicable

Conditions: Acute ischemic stroke

Registration Number: ChiCTR2400088952

Lead Sponsor: The Second Affiliated Hospital of the Army Medical University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

Aged 18 years or over; 2. The time of arrival at the hospital is not more than 24 hours from the onset of stroke or the last normal time; 3. Clinical diagnosis of AIS due to anterior/posterior circulation large vessel occlusion on DSA/CTA/MRA; 4. Alberta Stroke Program Early CT Score (ASPECTS) <= 2 on CT/MRI; 5. National Institute of Health stroke scale (NIHSS) >= 3; 6. Informed consent obtained from patients or their legal representatives. .

Exclusion Criteria

1.Confirmed intracranial hemorrhage through computed tomography (CT) or magnetic resonance imaging (MRI); 2.Pre-stroke modified Rankin Scale (mRS) score >= 2; 3.Pregnancy or breastfeeding women; 4.Genetic or acquired bleeding diathesis, deficiency of anticoagulant factors, or use of anticoagulant medication with an International Normalized Ratio (INR) > 3; 5.Presence of intracranial tumors with mass effect on imaging (excluding small meningiomas); 6.Any end-stage disease with expected survival less than 6 months; 7.Anticipated inability to complete follow-up; 8.Brain herniation causing midline shift; 9.Presence of severe complications that may affect patient prognosis and follow-up (cancer, severe heart failure, renal failure); 10. Suspected septic embolism or bacterial endocarditis; 11. Participating in other clinical trials;

Study & Design

Study Type: Observational study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The rate of 90-day modified Rankin scale (mRS) score 0-2(%);The rate of symptomatic intracerebral hemorrhage (SICH) at 48-hour and death at 90-day;

Secondary Outcome Measures

Name	Time	Method
The rate of 90-day modified Rankin scale (mRS) score 0-3(%);The rate of 90-day modified Rankin scale (mRS) score 0-1(%);Shift in the distribution of mRS scores at 90 days;EQ-5D score at 90 days;The rate of any type of intracranial hemorrhage at 48-hour;The rate of death at 7-day;