Comparison of ART Outcomes between Two Protocols of Induction of ovulation in Patients with Hypogonadotropic Hypogonadism
- Conditions
- •Female infertility associated with anovulation.Hypopituitarism
- Registration Number
- IRCT201312251141N16
- Lead Sponsor
- Royan Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria:
Have a clinical history of hypogonadotropic hypogonadism, and laboratory test result comply with diagnosis of hypogonadotropic hypogonadism; Have discontinued gonadotropins or gonadotropin releasing hormone or estrogen-progesterone replacement therapy at least one month before the study; Have primary or secondary amenorrhea; Serum LH and FSH <5.0 IU/l and oestradiol <100 pg/ml before initiation of treatment; Have a negative progesterone challenge test; Normal serum concentrations of thyroid stimulating hormone (TSH), prolactin and testosterone within 6 months before the start of study; Have given written informed consent prior to any study related procedure
The other causes of infertility; History of ovarian hyper stimulation syndrome; Abnormal gynecological bleeding of undetermined origin; Previous or current hormone dependent tumor
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number and size of follicles. Timepoint: Before injection of hCG. Method of measurement: Sonography.;Endometrial thickness. Timepoint: Day of injection of hCG. Method of measurement: Sonography.;The number of oocytes retrieved. Timepoint: 34-36 hours after hCG injection. Method of measurement: Sonography.
- Secondary Outcome Measures
Name Time Method Fertilization. Timepoint: 2-3 days before the embryo transfer. Method of measurement: observation of 2 pro-nuclei (2PN).;Biochemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: BhCG test.;Clinical pregnancy. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Ultrasound visualization of a gestational sac.;Implantation. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Number of gestational sacs by Sonography.