临床试验/NCT00823199

NCT00823199已完成不适用

An Open Trial of Allopurinol in Patients With Poorly Responsive Schizophrenia

Bronx Psychiatric Center0 个研究点目标入组 10 人开始时间: 2005年11月最近更新: 2018年8月21日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: Bronx Psychiatric Center
入组人数: 10
主要终点: Change in Positive and Negative Syndrome Scale (PANSS) Measures Symptoms of Schizophrenia

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者记录与标识符相似试验

研究概览

简要总结

This is a four week open label trial of ALLOPURINOL to the treatment regime of ten (10) poorly responsive patients with schizophrenia, monitoring their response and side-effects. No change in medication is required.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 65 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Subjects with schizophrenia and poor response (no prospect of discharge because of symptoms)

排除标准

•Renal or liver disease
•Hypertension
•Taking thiazides or ACE inhibitors

研究组 & 干预措施

Allopurinal treatment

Experimental

Allopurinal 300mg once daily by mouth for four weeks

干预措施: Allopurinal (Drug)

结局指标

主要结局

Change in Positive and Negative Syndrome Scale (PANSS) Measures Symptoms of Schizophrenia

时间窗: baseline and 4 weeks

Symptom scale Score 30 (best, no symptoms of schizophrenia) to 210 (worst)

次要结局

Simpson Angus Scale for Parkinsonism(baseline and 4 weeks)

研究者

发起方

Bronx Psychiatric Center

申办方类型

Other Gov

责任方

Principal Investigator

主要研究者

Nigel Bark MD

Director Schizophrenia Research

Bronx Psychiatric Center

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