Measuring of transcutaneous CO2 (tcCO2) in patients with a high risk for obstructive sleep apnea syndrome OSA perioperatively
- Conditions
- G47.31
- Registration Number
- DRKS00016997
- Lead Sponsor
- Klinik und Poliklinikfür Anästhesiologie und Intensivtherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Patients over the age of 18 who undergo elective low or medium risk surgery in visceral surgery, vascular surgery or trauma surgery requiring general anesthesia lasting at least one hour. Hospitalization should be scheduled for at least four days postoperatively to allow follow-up in the third postoperative night.
Exclusion Criteria
laparoscopic surgery, pulmonary intervention, epidural anesthesia, shock or systemic inflammatory response, patients with need of Admission to intensive care unit postoperative, emergency procedures, patients admitted to hospital at the day of surgery, contraindications to sevoflurane, chronic pain patients with pre-existing opioid therapy , COPD (GOLD =3), known arrhythmias
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Integral of the deviations of the drift-corrected tcCO2 values compared to baseline (measured at the beginning of the observed night) within the three study periods in the group comparison.
- Secondary Outcome Measures
Name Time Method Maximum increase in CO2 during study periods compared to baseline at the beginning of the study (baseline = mean of the first 15 min of measurement time as soon as the tcCO2 value is stable).<br>• Average number of saturation drops within one hour, with a drop being defined as a decrease in saturation of = 4% for at least 10 seconds.<br>• Comparison of PaCO2 with tcCO2 (in patients who have received an invasive blood pressure measurement for medical reasons) at the beginning and end of each measurement period.<br>• Complications occurring within the hospital stay (maximum 30 days) will be assessed against the standards of the European Society of Anaesthesiology and Intensive Care Medicine (EPCO).<br>• severe adverse cardiac events, pulmonary complications, non-invasive postoperative ventilation, re-intubation, ICU admission, delirium, difficult mask ventilation or intubation, use of naloxone<br>• Determination of characteristic deviations of the tcCO2 compared to the respiratory pattern