Effect of intrauterine administration of granulocyte-colony stimulating factor (GCSF) in IVF cycles on the fertility rate of infertile wome
- Conditions
- Infertility.Female infertility of other originN97.8
- Registration Number
- IRCT20110731007165N7
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 66
First time IVF due to infertility
Moderate to severe endometriosis (according to laparoscopic criteria, moderate endometriosis was defined as Adhesion affecting Fallopian tubes or ovaries, and severe endometriosis was defined as the involvement of Fallopian tubes, ovaries, and cul-de-sac)
Age 18-40 years
Fertility due to endometriosis
Moderate -to –severe endometriosis was characterized by endometrial glands and stroma at least 5 mm beneath the peritoneum or an ovarian endometriotic cyst (endometrioma)
Male factor infertility.
Evidence of a significant decrease in the ovarian reserve (FSH>11, AMH<0.5, decreased AFC),
Endocrine disorders (diabetes, thyroid diseases, hyperprolactinemia, hypothalamic amenorrhea, etc.)
, confirmed medical and immunologic diseases (SLE, rheumatoid arthritis, antiphospholipid syndrome, cardiovascular, liver, and renal diseases),
and congenital uterine anomalies and uterine cavity disorder (bicornuate uterus, unicornuate uterus, Asherman syndrome, myoma, polyps, etc.).
Donation candidates (ovum donation and surrogate utrus) were also excluded from the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pregnancy. Timepoint: 3 weeks after embryo transfer. Method of measurement: Vaginal ultrasound.
- Secondary Outcome Measures
Name Time Method