Adipocytokine levels in obese children before and after lifestyle interventio

Completed

• Conditions: Obesity; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN71948313
• Lead Sponsor: Regional Hospital Viborg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09-10
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Aged between 11-13 years
2. BMI = 22 (this value at the age of 12 years old correlates to BMI of 25 in an adult)

Exclusion Criteria

Considerable comorbidity which would make participation in structural physical activity impossible.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The degree of weight loss and weight changes. Weight, height and BMI was registrated every third month during the intervention period. <br>2. Changes in adiponectin, leptin and c-reactive protein (CRP) are measured before and after the intervention. Adiponectin (mg/l) is determined by a validated in-house time-resolved immunofluorometric assay based on two monoclonal antibodies and recombinant human adiponectin (obtained from R&D Systems, Abingdon, UK). Leptin (µg/l) is determined by a validated in-house time-resolved immunofluorometric assay based on commercial available monoclonal antibodies and recombinant human leptin (R&D Systems, Abingdon, UK). CRP levels are determined by a high sensitive CRP (hsCRP) TRIFMA assay based on commercial available monoclonal antibodies (R&D systems).

Secondary Outcome Measures

Name	Time	Method
1. Waist circumference, measured every third month during the intervention.<br>2. Hip circumference, measured every third month during the intervention.<br>3. Blood pressure, measured every third month during the intervention.