Relationship between epidural steroid dose and HPA axis suppression: Double blinded, Randomized controlled trial
- Conditions
- Diseases of the musculo-skeletal system and connective tissue
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 34
participants met the American Society of Anesthesiologists Physical Status 1 or 2 classification; adults aged over 50 years; men and postmenopausal women; patients diagnosed with lumbar HNP or spinal stenosis on the basis of symptoms (pain nature, pain location, neurogenic intermittent claudication, pain aggravating or relieving factors, etc.), signs (straight leg raising test, sensory, motor, deep tendon reflex, etc.), and magnetic resonance imaging (MRI) findings; and patients who were matched for ESI.
patients absolutely contraindicated for ESI (bleeding tendency and infection at the procedure site); patients who had received any glucocorticoids during recent 3 months; patients who could not take glucocorticoids (allergy to steroid agents, pregnancy, all endocrinological diseases); patients with sleep disturbances; patients taking herbal medicine or contraceptives; patients who had experienced severe stress during the preceding month; and patients who had consumed alcohol for 12 hours or food one hour before sampling.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method salivary cortisol level
- Secondary Outcome Measures
Name Time Method Extend of reduction (%) of SC concentration after ESI =(SC on D0 - SC on D1) / SC on D0 × 100;ACTH stimulation test;Numerical rating scale (NRS)