Cardiac Imaging in congenital aortic stenosis: unravelling risk factors and predicting clinical outcome

Recruiting

• Conditions: bicuspid aortic valve; Congenital aortic stenosis; 10007510

• Registration Number: NL-OMON52322
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

The study population consists of 100 adult ConAoS patients, who are visiting
the outpatient clinic of the Erasmus MC.
In order to be eligible to participate in this study, a subject must meet the
following criteria:
• Aged >= 18 years
• Capable of understanding and signing informed consent.

Inclusion criteria for the CAS study are patients diagnosed with a valvular
congenital aortic stenosis. Two groups of patients will be included:
• Patients with a prior aortic valve replacement (AVR)
• Patients without a prior AVR and with an aortic jet velocity >= 2.5 m/s.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
• Patients with severe aortic regurgitation
• Presence of any of the following contra-indications for MRI
o Contra-indication to gadolinium based contrast media (eGFR <30
ml/min or contrast allergy)
o Other contra-indications such as presence of pacemaker/ICD, severe
claustrophobia or pregnancy
• Patients known with or previously treated because of significant aortic
coarctation.
• Patients known with genetic syndromes or connective tissue disorders

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the prevalence and patterns of myocardial<br /><br>fibrosis.</p><br>