Fusion of Cardiac Computed Tomography Angiography (CTA) and 18F-Fluorodesoxyglucose Positron Emission Tomography (FDG-PET) to Determine Normal Peri-annular FDG Uptake after Aortic Valve Implantatio

Recruiting

• Conditions: endocarditis; prosthetic heart valve; 10046973

• Registration Number: NL-OMON43910
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

- age > 50 years
- patients after uncomplicated PHV implantation
- Normal routine follow-up TTE
- 5 weeks or 12 weeks or 12 months after PHV implantation
- weight < 110 kg

Exclusion Criteria

- Known contrast allergy
- Known renal impairment (GFR<60)
- Other contraindications for contrast use according the standard daily clinical routine
- Use of pericardial patches and re-operation of aortic PHV in past medical history
- Contraindication for Computed Tomography Angiography according the standard daily clinical routine

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>18F-FDG/PET baseline uptake measured by the QVSH value and the SUV ratio*s<br /><br>around the PHV in early, late and possibly also in the chronic postoperative<br /><br>phase: 5 (± 1) weeks, 12 (± 2) weeks and 12 (± 2) months respectively.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Feasibility of hybrid fusion (diagnostic CTA and PET): percentage of<br /><br>patients for which it is possible to fuse FDG-PET images and cardiac CTA<br /><br>images<br /><br><br /><br>- Artefacts (region, extend and type and location) during assessment with<br /><br>FDG-PET/CTA will be described</p><br>