Cardiac computed tomography (CT) for the Assessment of chest Pain and Plaque

Not Applicable

Completed

• Conditions: Coronary artery disease; Circulatory System; Heart disease

• Registration Number: ISRCTN52480460
• Lead Sponsor: lster Hospital (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09-07
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

1. Patients over 40 referred to the Rapid Access Chest Pain Clinic (RACPC), Ulster Hospital, Northern Ireland for suspicion of angina
2. Patients must have the ability to hold breath

Exclusion Criteria

1. Less than 40 years of age
2. Significant renal dysfunction with an estimated Glomerular Filtration Rate (eGFR) less than 35. As the contrast used in CCT and conventional angiography can cause contrast nephropathy these patients with will be excluded from the study
3. Recent history of alcohol, drug abuse, or other medical conditions that might compromise safety, successful completion of, or drug compliance during the study
4. Patients with a history of chronic inflammatory conditions, such as severe arthritis, lupus, or inflammatory bowel disease, as well as subjects taking immunosuppressant agents, such as cyclosporine, tacrolimus, azathioprine, or chronic oral glucocorticoids. Because High-Sensitivity C-Reactive Protein (hs-CRP) will be measured, patients with other conditions that may cause a chronically elevated CRP will be excluded.
5. Unstable angina pectoris
6. Uncontrolled fast atrial fibrillation or other arrhythmias that may interfere with ECG-gated triggering of CT
7. Patients with extreme tachycardia, greater than 110 bpm, despite rate controlling agents
8. Pregnancy
9. Morbid obesity (Body Mass Index [BMI] >35)
10. Known contrast medium allergy
11. Known ischaemic heart disease with previous intervention in the form of coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI)
12. Inability to lie flat.
13. Severe Aortic Stenosis (clinically suspected and confirmed by echocardiogram)
14. Acute myocarditis/pericarditis
15. Uncontrolled hypertension >220/100
16. Severe peripheral vascular disease or impaired immobility
17. Severe mental disability that would impair capacity to consent
18. Significant COPD that would impair exercise or B blocker use
19. Left bundle branch

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in scores from baseline at 3 months on the physical limitation scale of the SAQ-UK

Secondary Outcome Measures

Name	Time	Method
1. The cost effectiveness of cardiac CT as a primary diagnostic strategy will be compared with the costs associated with the current standard of care<br>2. Health-related quality of life<br>3. Cumulative radiation exposure<br>4. Resource utilisation