Coronary CT Angiography for Improved Assessment of Suspected Acute Coronary Syndrome with Inconclusive Diagnostic Work-up
- Conditions
- heart attacknon-ST elevation acute coronary syndrome10011082
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 240
Patients eligible for inclusion are aged between 30 and 80 years and present to the emergency department with symptoms suggestive of non-ST elevation acute coronary syndrome. These patients have a normal or non-diagnostic ECG. High-sensitivity levels are slightly elevated but under the limit for definitive diagnosis of acute myocardial infarction. During serial sampling there is no more than 40% rise or fall.
Inability or unwillingness to provide informed consent.
History of proven CAD, defined as documented prior myocardial infarction, percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery.
Previous examination with either invasive angiography or CCTA in the last 3 years.
Clinical instability: clinical heart failure, hemodynamic instability, severe chest pain.
CCTA¬-specific contra¬indications:
o Allergy to iodine contrast media
o Pregnancy
o Impaired renal function: estimated glomerular filtering rate <45 ml/min
o Severe arrhythmia likely to affect image interpretation
o BMI > 40 kg/m2
o Inability to cooperate during the examination.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The negative predictive value of CCTA for NSTE-ACS.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1) Predictive value of CCTA for major cardiac adverse events: death, non-fatal<br /><br>myocardial infarction and coronary revascularisation at 6 months.<br /><br>2) Determine the prevalence of atherosclerosis, extent and type and correlate<br /><br>with clinical factors.<br /><br>3) Potential benefit of FFR-CT in the diagnosis of NSTE-ACS.</p><br>