Mind the Heart: diagnostic yield of cardiac CT-angiography in the acute phase of ischemic stroke

Recruiting

Conditions: stroke
Ischemic stroke
10082206
10007963
10014523

Registration Number: NL-OMON50352

Lead Sponsor: eurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 450

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
• Age >= 18 years;
• Clinical diagnosis of acute ischemic stroke;
• Candidate for reperfusion therapy (thrombolysis, thrombectomy);
• Informed consent from patient or representative after the standard practice
CTA of heart, aortic arch, cervical arteries and brain.

Exclusion Criteria

• Patients with another diagnosis such as transient ischemic attack (TIA),
intracerebral hemorrhage, subarachnoid hemorrhage or tumor;
• No CTA of the heart performed;

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Proportion of acute ischemic stroke patients in which a high-risk cardio-aortic<br /><br>source is established with CTA compared to transthoracic echocardiography. For<br /><br>specification of cardio-aortic causes of ischemic stroke, please see C1<br /><br>onderzoeksprotocol 'Main study parameter/endpoint'.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Comparison of two diagnostic strategies (CTA vs TTE), expressed as proportion<br /><br>of patients in which a high-risk cardio-aortic source is established with CTA,<br /><br>compared to TTE (this analysis also includes patients who did not undergo TTE).<br /><br>Inter-observer variability of interpretation of cardio-aortic CTA images<br /><br>Cardiac treatment received within 90 days and 2 years, including time between<br /><br>onset of stroke and cardio-aortic treatment<br /><br>Recurrent stroke within 90 days and 2 years<br /><br>Modified Rankin Scale (mRS) score at 90 days (standard care) and 2 years (for<br /><br>the purpose of the study)<br /><br>Male/female differences in occurrence, subtype, treatment and outcome of<br /><br>cardio-aortic causes of acute ischemic stroke<br /><br>Proportion of cardiac thrombi, identified on CTA of the heart, which dissolve<br /><br>on sequential imaging at 24 hours and 7 days after initial CTA imaging</p><br>