Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients
Completed
- Conditions
- Severe BurnAntibioticsIntensive Care
- Registration Number
- NCT03335137
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Brief Summary
At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
General
- Adult
- Receiving beta-lactam antibiotic Piperacillin/Tazobactam
- Antibiotic therapy of 3 or more days
- Given informed consent Group 1
- Severe Burn Group 2
- No Severe Burn
Exclusion Criteria
- Already in another Study
- No useful blood sample
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Schleswig-Holstein
🇩🇪Lübeck, Schleswig-Holstein, Germany
University Hospital Schleswig-Holstein🇩🇪Lübeck, Schleswig-Holstein, Germany