NCT02446392已完成不适用
The Distribution of Plasma Drug Concentrations of Beta-lactam Antibiotics in Intensive Care Unit Patients
Linkoeping University2 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2014年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- The rate of patients below 16mg/L for piperacillin-tazobactam, 2 mg/L for meropenem and 4mg/L for cefotaxim
研究概览
简要总结
In this project, intensive care unit (ICU) patients treated with beta-lactam antibiotics are included with the aim to investigate the potential underdosing in this patient group. Four regional ICU-clinics are recruiting consecutive patients (n=120) and samples are taken before the next dose is administered for three consecutive days.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Current treatment with beta-lactam antibiotics and admission to the ICU
排除标准
- •Pregnancy, age below 18 years
结局指标
主要结局
The rate of patients below 16mg/L for piperacillin-tazobactam, 2 mg/L for meropenem and 4mg/L for cefotaxim
时间窗: 3 days
次要结局
- Mortality in relation to initial levels of beta-lactam antibiotics as defined in primary outcome(30 days)
- The rate of patients below 100% time over MIC in relation to the bacteria causing the infection.(3 days)
- Kidney function measured as eGFR in relation to initial levels of beta-lactam antibiotics as defined in primary outcome(3 days)
- SAPS-score in relation to initial levels of beta-lactam antibiotics as defined in primary outcome(3 days)
- Days in intensive care unit in relation to initial levels of beta-lactam antibiotics as defined in primary outcome(30 days)
研究者
Thomas Schon
MD PhD (Associate professor)
Linkoeping University
研究点 (2)
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