Descriptors of Neuropathic Spinal Pain and Their Relations With Functional Status in Ankylosing Spondylitis Patients
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Neuropathic pain descriptors
研究概览
简要总结
The investigators have aimed to explore and interpret the neuropathic pain (NP) descriptors of spinal pain in patients with ankylosing spondylitis (AS). For this purpose they have attempted to initiate a prospective, cross-sectional study with AS patients.
详细描述
NP descriptors have been investigated in several pain syndromes such as post-herpetic neuralgia, post-surgical nerve trauma, peripheral diabetic neuropathy and low back pain. But there is no study examining descriptors of inflammatory spinal pain with or without neuropathic characteristics seen in AS. To date, only one study reported distribution of sensory descriptors in neuropathic and non-neuropathic pain (nonNP) in AS patients, but in this paper the painful region was not specified and the results related to sensory descriptors were not discussed. Therefore, investigators have aimed to explore and interpret the sensory descriptors of inflammatory spinal pain in patients with AS. For this purpose investigators have attempted to initiate a study investigating whether sensory descriptors in neuropathic pain (NP) are differ from those seen in non-neuropathic pain (nonNP).
The aims of this study are;
- To determine NP descriptors that associated with spinal pain in ankylosing spondylitis patients
- To compare the patients with and without NP with respect to sensory descriptors
- To evaluate the relation between neuropathic pain (NP) descriptors and functional status
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being diagnosed with AS according to the Modified NewYork Criteria
- •Visual Analogue Scale spinal pain score ≥ 3
排除标准
- •Diabetes mellitus, renal insufficiency, hypothyroidism
- •Postherpetic neuralgia, spinal cord compression
- •Being diagnosed as fibromyalgia in the last month or widespread pain indicating fibromyalgia
- •Severe cardiac disease
- •In the last three months medical treatment leading to neuropathy (colchicine etc.)
- •In the last three months drug use for the treatment of fibromyalgia, depression or anxiety
结局指标
主要结局
Neuropathic pain descriptors
时间窗: Once, at baseline
In the painDETECT questionnaire, seven items querying sensory abnormalities are scored between 0-5. Each of these abnormal sensations represent a pain descriptor. These descriptors are; burning, tingling, allodynia, pain attacks, thermal hyperalgesia, numbness and pressure hyperalgesia. A descriptor will accepted as positive if it is scored between 3 to 5
Neuropathic pain
时间窗: Once, at baseline
It will be assessed using the painDETECT questionnaire. This questionnaire, contains nine questions all of which are selfreport. Seven items are rated on a six point Likert scale and thus are scored between 0-5. These seven questions query some sensations such as burning, tingling or prickling, allodynia, numbness etc. Apart from these seven items, one item assesses the radiation of pain and the other one item looks for the temporal characteristics of pain. A total score of 12 or less indicates neuropathic component is unlikely, 13-18 means possible neuropathic component and 19 or greater means a neuropathic component is likely. Beside these, there are three items in a separate section measuring severity of pain at the time of evaluation, on average and maximum over the past month. This section is not taken into account in scoring.
次要结局
- Functional status(Once, at baseline)
研究者
Taciser Kaya
Professor, MD
Bozyaka Training and Research Hospital