Symptom-Based Treatment for Neuropathic Pain in Spinal Cord Injured Patients, Randomized Clinical Trial
Overview
- Phase
- Phase 4
- Intervention
- Pregabalin and Oxcarbazepine
- Conditions
- Neuralgia
- Sponsor
- Ju Seok Ryu
- Enrollment
- 63
- Locations
- 1
- Primary Endpoint
- Symptom based treatment of neuropathic pain
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
-
Neuropathic pain in spinal cord injured patients
-
Inclusion criteria
- pain intensity, visual analogue scale > 3
- a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
- aged ≥20
-
Method
- Stop pain medications
- Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily)
- Check pain intensity (VAS score) with Baron's classification
Detailed Description
In the present study, pharmacologic treatment included pregabalin and oxcarbazepine. Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain and the central nervous system prior to the study for at least 3 days. 1. Pain intensity (VAS score) 1. 4 spontaneous characters * electric * burning * pricking * numbness 2. evoked pain * allodynia * heat hyperalgesia * pressure hyperalgesia 2. Location of neuropathic pain 1. neuropathic pain at level of spinal cord injury 2. neuropathic pain below level of spinal cord injury 2. Side effects
Investigators
Ju Seok Ryu
Assistant professor
CHA University
Eligibility Criteria
Inclusion Criteria
- •aged than 20 years
- •Neuropathic pain symptoms : LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
- •Visual analogue scale score of 3 and above
Exclusion Criteria
- •No pregnancy
- •systemic disease
- •psychiatric disease
Arms & Interventions
Pregabalin and Oxcarbazpepine
Pregabalin and Oxcarbazepine
Intervention: Pregabalin and Oxcarbazepine
Outcomes
Primary Outcomes
Symptom based treatment of neuropathic pain
Time Frame: 2 week later
Pain intensity using Visual analogue scale (0\~100)