Evaluation of Neuropathic Pain in Patients With Psoriatic Arthritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Psoriatic Arthritis
- Sponsor
- Bezmialem Vakif University
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Short form-36 survey in two groups
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Pathogenesis of inflammatory diseases is suitable for eliciting neuropathic pain. The aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life, functionality, and other numerous factors.
Detailed Description
Neuropathic pain (NP) is the pain arising from a primary lesion or a dysfunction of nervous system. NP can affect central or peripheral nervous system and can be caused by numerous factors such as inflammation or neuroplastic changes. Inflammation can sensitize nociceptors in sensory nerves by promoting prostaglandin E2 and I2 secretion thus, cause neuropathic pain. Besides, a mixed pain pattern with neuropathic components is thought to be developed in chronic pain conditions. In this point of view, pathogenesis of inflammatory diseases is suitable for eliciting NP. In arthritic joints, even non-arthritic tissues are affected by the disease and a condition called peripheral sensitization develops. Previous studies about NP and inflammatory diseases link have focused on rheumatoid arthritis and number of studies about NP and psoriatic arthritis (PsA) is limited. In this manner the aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life, functionality, and other numerous factors.
Investigators
Eligibility Criteria
Inclusion Criteria
- •being aged≥18
- •being diagnosed PSA according to CASPAR criteria
Exclusion Criteria
- •additional conditions that could cause neuropathic pain (e.g. radiculopathy, polyneuropathy, depression, fibromyalgia)
- •history of fracture or surgery
- •endocrinopathies that could cause neuropathic pain (e.g. DM)
- •malignancy
Outcomes
Primary Outcomes
Short form-36 survey in two groups
Time Frame: 1 day
The statistical difference between two groups in terms of SF-36 and subdomains
Frequency neuropathic pain in psoriatic arthritis patients
Time Frame: 1 day
The frequency of neuropathic pain in the PSA patients included in the study according to painDETECT and DN4 scores.
Disease activity in Psoriatic arthritis (DAPSA) score in two groups
Time Frame: 1 day
The statistical difference between two groups in terms of disease activity
Numeric Rating Scale (rest, movement) in two groups
Time Frame: 1 day
The statistical difference between two groups in terms of disease activity
SPARCC enthesitis index in two groups
Time Frame: 1 day
he statistical difference between two groups in terms of SPARCC