Diagnostic Value and Biological Significant of cd71 in Lymphoid Disorders

• Conditions: cd71; Lyphoid Disorders

• Registration Number: NCT03720977
• Lead Sponsor: Marwa Aboelim Shafeik

Brief Summary

CD71 is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues. , reflecting the requirement for iron in hemoglobin. , CD71 expression is upregulated on immature proliferating cells and low levels on resting mature lymphocytes. In addition to this general function, CD71 appears to play a costimulatory role in T cell activation and receptor for IgA1 antibodies So it is growth receptor that may help in diagnosis of lymphoid disorder and in differentiation of malignant and benign that will be studied investigate CD71 expression in lymphoid disorders and its diagnostic value ,we from collect data patient and do rotune examination

Detailed Description

1. Routine investigations for diagnosis:

* CBC.

* Bone marrow aspiration morphology.

* Cytochemistry.

* Flow cytometry immunophenotyping.

* Bone marrow biopsy when indicated.

2. Special investigation is flow cytometry examination of CD71 expression.

sample size calculation ; sample size cases 39 sample size controls 39 total sample size 79 sample will be collected from patient in hospital university ,Data will be analysed by SPSS program

Study Timeline

• Status Verified: 2018-10
• Study First Submitted: 2018-10-18
• Study First Submitted QC: 2018-10-24
• Last Update Submitted: 2018-10-24
• Study First Posted: 2018-10-26
• Last Update Posted: 2018-10-26
• Study Start: 2019-12-01
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 139

Inclusion Criteria

• all patients wiil be diagnosed lymphoid disorders

Exclusion Criteria

• not present

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
determin diagnostic value of cd71 in lymphoid disorder	baseline	Routine investigations for diagnosis: CBC. Bone marrow aspiration morphology. Cytochemistry. Flow cytometry immunophenotyping. Bone marrow biopsy when indicated. Special investigation is flow cytometry examination of CD71 expression.; total sample size 79 person .sample will be collected from patient in hospital university ,Data will be analysed by SPSS program it is growth receptor is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues