Regional Anesthesia for Thyroidectomy

Not Applicable

• Conditions: Acute Pain; Chronic Pain
• Interventions: Procedure: nerve block; Procedure: placebo

• Registration Number: NCT02108834
• Lead Sponsor: Guangzhou First People's Hospital

Brief Summary

For more than 25 years, Regional Anesthesia has challenged anesthesiologists to determine whether it offers real benefits in terms of patient outcome from major surgery, compared with general anesthesia. Although it is clear that regional analgesia in association with general anesthesia substantially reduces postoperative pain, the benefits in terms of overall perioperative outcome are controversial. The aim of this study is to evaluate the effect on short and long-term postoperative outcomes of adding regional analgesia to general anaesthesia in thoridetomic patients.

Detailed Description

Patients who are divided into two treatment groups: (a) a bilateral superficial cervical plexus group (group S) and a control group (group C).We performe bilateral superficial cervical plexus block (BSCPB)with 0.25-0.75% ropivacaine10 ml to group S and 10ml NaCl 0.9% to group C. All BSCPB is performed by experienced anesthesia doctor after a standardized induction of general anaesthesia.eneral anaesthesia was induced by using intravenously with midazolam,propofol, fentanyl, cisatracurium is injected IV to facilitate orotracheal intubation. After a standardized induction of general anaesthesia, patients receive Regional Anesthesia at the discretion of the experienced anesthesiologist who was blinded to treatment.

The patient is placed in a supine position with the head turned away from the side to be blocked, and then the sternocleidomastoid muscle (SCM) is identified by slight head elevation. SCPB is performed with a 26-gauge needle that is inserted at the midpoint of the posterior border of the SCM muscle and the needle is advanced just past the SCM muscle.

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2014-04-04
• Study First Submitted QC: 2014-04-06
• Study First Posted: 2014-04-09
• Status Verified: 2015-01
• Last Update Submitted: 2015-01-19
• Last Update Posted: 2015-01-21
• Primary Completion: 2015-02
• Study Completion: 2015-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

-Eligible patients fit an ASA I or II classification adult patients who will be scheduled for elective thyroid lobectomy under general anaesthesia.

Exclusion Criteria

• hypersensitivity to any study drugs
• Long-term use of anticoagulant drugs: warfarin or heparin
• the neck or systemic infection
• communication disorder
• refuse to accept this research subjects.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
nerve block	nerve block	cervical plexus block with ropivacaine
Placebo	placebo	placebo saline

Primary Outcome Measures

Name	Time	Method
the incidence of chronic postsurgery pain	60 days	the time from the end of surgery

Secondary Outcome Measures

Name	Time	Method
hemodynamic stability	1 day	blood pressure and heart rate intraoperative responses.
postoperative nausea and vomiting	2 days after operation
the intensity of acute pain	24 hours	swallowing pain and rest pain

Trial Locations

Locations (1)

Guangzhou First Municipal People's Hospital; 🇨🇳 Guangzhou, China