The effects of synbiotic supplementation on dietary intake?nutritional status, quality of life, serum Matrix Metalloproteinase enzymes,serum inflammatory markers levels(TNFa,IL-6) and side effects of treatment in rectal cancer patients undergoing neoadjuvant chemoradiotherapy
Not Applicable
- Conditions
- Rectal cancer.Malignant neoplasm of rectum
- Registration Number
- IRCT201503181197N18
- Lead Sponsor
- utritional Research Center,Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 46
Inclusion Criteria
patients with rectal cancer in stage 2 and 3 undergoing preoperative radiotherapy combined with chemotherapy.
Exclusion criteria: clinically relevant pulmonary; cardiovascular; hepatic and kidney dysfunction; immunological disorders; pregnancy; lactation; ongoing or recent infections (within last 30 d); body mass index less than 18.5 ; treatment with anticoagulants; taking antibiotics in the last 3 week; usage of Probiotics or prebiotics or synbiotic and mineral supplements; intolerance of synbiotic supplement.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum inflammatory factor TNFa, serum inflammatory factor IL-6. Timepoint: Before radiotherapy and at the end of intervention(6 weeks). Method of measurement: Immunoturbidimetry.
- Secondary Outcome Measures
Name Time Method Dietary intake. Timepoint: Before radiotherapy and at the end of intervention(6 weeks). Method of measurement: 24 hour food recall and dietary record questionnaire.;Quality of life. Timepoint: Before radiotherapy and at the end of intervention(6 weeks). Method of measurement: QLQ-30 questionnaire.;Serum Matrix Metalloproteinases 2 ,9 (MMP-2,9). Timepoint: Before radiotherapy and at the end of intervention(6 weeks). Method of measurement: MMP-2,9;kit.;Added at 2016-02-28: side effects of treatment?. Timepoint: Added at 2016-02-28: before radiotherapy and at the end of intervention. Method of measurement: Added at 2016-02-28: PG-SGA and WHO toxicity criteria questionnaire.