The effect of synbiotic supplementation on inflammation in Breast Cancer survivors with Lymphedema
- Conditions
- lymphedema.Breast, unspecified
- Registration Number
- IRCT2017092023861N7
- Lead Sponsor
- Vice chancellor of research, Iran University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 88
women with unilateral breast cancer related lymphedema ; breast cancer lymphedema in stage 2; Age range between 18 to 60 years ; BMI between 25 to 35 Kg/m2 ; At least one month has passed since the last treatment such as radiotherapy; Willingness to participate in the study ; Non-inclusion criteria: Use of multivitamin minerals and omega 3 supplements up to 1 month before the study began; Inflammatory diseases such as heart failure, pulmonary, kidney and diabetes; autoimmune diseases such as rheumatoid arthritis; Acute and chronic infection; taking Probiotics supplementation from 6 months before study; having a weight loss diet in Length 6 months before the study ; Smoking and Alcohol consumption; Lymphedema due to other cancers; Exclusion criteria: Cancer recurrence during the study; Metastasis; Diseases leading to edema such as renal, cardiopulmonary and pulmonary failure during the study; Infectious diseases during the study; Consumption of food and supplements containing probiotics during the study; Failure to follow the weight loss diet; Consumption less than 56 capsules; Unwillingness to continue cooperation
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tumor necrosis factor alpha. Timepoint: Before intervention and 10 weeks after the start of intervention. Method of measurement: ELISA.
- Secondary Outcome Measures
Name Time Method