Protocol for Evaluation of Quarter-Time Cardiac Imaging: 5-Minutes Rest and 3-Minutes Stress Wide Beam Reconstruction (WBR) Versus Full-Time Filtered Back Projection (FBP)

Completed

• Conditions: Cardiac Diseases

• Registration Number: NCT00661752
• Lead Sponsor: St. Luke's-Roosevelt Hospital Center

Brief Summary

A new, innovative software image processing method, wide beam reconstruction (WBR), utilizes resolution recovery and incorporates Poisson noise-reduction into the reconstruction process of NM images. This method facilitates the reconstruction of low count density myocardial perfusion SPECT images. Preliminary research indicates that SPECT acquisition time consequently can be reduced by 60% (less than 5 minutes) for rest and by 75% (just over 3 minutes) for stress, while tomographic image quality is maintained, or even improved. Such a decrease in image acquisition time decreases patient discomfort during the tomographic acquisition, decreases the opportunity for patient motion, and improves laboratory efficiency.

Detailed Description

Standard full-time SPECT will be processed using FBP and compared to 3-minute stress and 5-minute rest scans processed with WBR. The following scan parameters will be evaluated: image quality; perfusion defect extent, severity, and reversibility; transient ischemic dilatation; left ventricular end-diastolic volume; left ventricular end-systolic volume; left ventricular ejection fraction; and regional wall motion and wall thickening abnormalities. These parameters will be assessed visually by experienced Nuclear physicians (at least 2 blinded readers) and quantitatively using several different commercially available software programs.

Study Timeline

• Study Start: 2007-05
• Primary Completion: 2007-08
• Study Completion: 2008-01
• Study First Submitted: 2008-04-08
• Study First Submitted QC: 2008-04-17
• Study First Posted: 2008-04-18
• Status Verified: 2008-08
• Last Update Submitted: 2008-08-25
• Last Update Posted: 2008-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 134

Inclusion Criteria

• Patient is clinically stable
• Patient is able to tolerate additional 8 minutes of scanning
• Patient is willing to undergo additional 8 minutes of scanning

Exclusion Criteria

• Unstable patient
• Non-consenting patient

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Image quality of quarter-time WBR images is equivalent/superior to full-time FBP	March 2008

Secondary Outcome Measures

Name	Time	Method
Image quality of quarter-time WBR is equivalent/superior to half-time WBR	March 2008