SPECT Myocardial Perfusion Reserve Using a Cadmium Zinc Telluride (CZT) Camera in Cardiovascular Risk Stratification and Ischemia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ischemia, Myocardial
- Sponsor
- Centre Hospitalier Régional d'Orléans
- Enrollment
- 137
- Locations
- 2
- Primary Endpoint
- Regional and global CFR
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
CFR has been studied for few years using 82 Rubidium PET (positron emission tomography) /CT. CFR has shown to be correlated with cardiovascular events occurring in the 10 following years. CFR also helps to identify multivessel coronary disease. Few studies have shown the possibility to calculate CFR during myocardial perfusion SPECT on new ultrafast CZT cameras.
Detailed Description
Evaluate the contribution of CZT SPECT CFR in cardiovascular risk stratification: correlation with clinical scores, with calcium score, and when pathological with coronarography findings especially fractional flow reserve (FFR).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients referred for myocardial ischemia screening
Exclusion Criteria
- •Patient already suffering from coronary disease with angioplasty, bypass surgery or myocardial infarction.
- •Contraindications related to the stress test:
- •Acute Coronary Syndrome \<5 days Unstable angina Stenosis of left main artery untreated Uncontrolled severe rhythm disorders Uncontrolled heart failure
- •Contraindications to dipyridamole and regadenoson:
- •Hypotension (systolic \<90mmHg) Severe pulmonary arterial hypertension Bradycardia \<40 beats / minute Sinusal Dysfunction and 2nd or 3rd degree Atrioventricular block Decompensated Heart Failure with Ejection Fraction \<25% Stenosis of supra-aortic trunks unilateral\> 70% or bilateral\> 50% Dipyridamole and regadenoson allergy
- •Patients with pacemaker, or who have had valvular surgery,
- •Well-known dilated cardiopathy
- •Pregnant or breastfeeding women,
- •Minor people
- •Persons under guardianship or under guardianship
Outcomes
Primary Outcomes
Regional and global CFR
Time Frame: Day 0
Regional and global CFR calculated from CZT SPECT myocardial perfusion: correlation with clinical score and calcium score
Secondary Outcomes
- FFR Regional CFR after one year of medical treatment(Up to one year)