Estimation of sRANKL and Osteoprotegerin in the gingival crevicular fluid during orthodontic tooth movement

Manipal College of Dental Sciences0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•1) Age group of 13-30 years
•2) Minimum of 20 remaining teeth
•3) Need for fixed appliance therapy involving tooth extractions
•4) Good general and periodontal health (probing depths not exceeding 3 mm in the whole dentition, no radiographic evidence of periodontal bone loss, no more than 10% of sites with bleeding on probing, and no gingival redness or edema)

•1)Patients who would not give informed consent
•2)Previous history of habits such as alcohol consumption or tobacco use
•3)Ongoing orthodontic or orthopedic therapy
•4)Any systemic condition that could affect periodontal status and bone metabolism or that would require premedication for monitoring or treatment procedures (eg, heart conditions, joint replacements, hormonal or bisphosphonate antiresorptive therapies, and chronic therapy with heparin or corticosteroids)
•5)Use of antibiotics, corticosteroids, or anti-inflammatory drugs within the last 3 months
•6)Professional cleaning or periodontal treatment within the last 6 months.

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